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I have a Focusrite Saffire Pro24 with two front inputs that supply 48V phantom power through a XLR/TRS combo jack. I have a condenser microphone connected to the first channel, so I have the phantom power active. I want to connect my acoustic guitar's line output to the second channel, but I don't want to damage its onboard pickup - I'd be using a TRS to TRS cable, though I've heard most instruments are TS wired. The Saffire Pro24 only allows you to turn the phantom power option on or off for both channel one AND two, not individually. I am wondering if I can use this front input without fear of damage, or do I need to see about getting a higher-end interface that allows individual control of phantom power to the front inputs.

Phantom power should only be on the XLR jack conductors, not on the 1/4" jack conductors, even when the I/O box has a combo XLR+1/4" jack. The problem would be if you tried to use an XLR to 1/4" stereo plug (TRS) cable adapter, when the XLR has phantom power.

Also I have once encountered a mixing console that put phantom power on every XLR output which my JBL monitor did not like.

What helped was inserting a DI box in between.

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