There are a lot of newbies in here (myself included although I've owned a Karma for a few years). So I thought it would be a nice addition to this forum to have a thread for tips and tricks that can be done on the Radias. The tricks don't necessarily have to be only possible on the Radias, and can also be more general tricks and tips for analog modelling synths.
When I use the Radias, I discover new possibilities all the time, and I'm sure others experience the same. By sharing this knowledge, we could all become better synth programmers.

So here goes my first tip:
Have you used up both step sequencers on other timbres and need another one? Set up one of the Modulation sequencers (you have 3 of these for each timbre) to control pitch. Set it to control the pitch in a stepped fashion instead of gliding between notes. Check out page 92 in the manual for info about the mod sequencers. You can then enter a pitch value for each step in the mod sequencer. This can be used to create entire looped riffs without the use of step sequencers.
To create a very simple analog drum sound to go with this loop, you can set one of the LFO's to a Saw waveform (check page 90 in the manual for info about LFO's). Turn on TempSync to synchronise the speed of the LFO with the speed of the modulation sequencer used for the riff. Set the KeySync parameter on both the LFO and Mod sequencers to Timbre to make sure they are synchronised all the time. Using a Virtual Patch (page 91), you can set that LFO to control Noise level. Because you chose a Saw waveform for the LFO, the noise will come in suddenly and fade out for every cycle the LFO does. Adjust the speed of the LFO and the control amount of the virtual patch until it sounds good.
The same LFO technique can be used to control the volume level or filter cutoff on the oscillator or oscillators used for the looped mod sequencer riff, so you get a little bit of punch for each "note" played.
Add a little bit of distortion or tube pre amp sim as insert effect 1 for that analoge sound and some tape echo on insert effect 2. Voila - you are in analog heaven using no step sequencers and only one note of polyphony in only one timbre for a synth riff with a drum to go with it!
Here's a youtube demo:
http://www.youtube.com/watch?v=hQCDXRs3O7A